Description
Recombinant human c-MER (A708S)(578-872) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The c-MER gene accession number is NM_006343.
c-MER is a member of the TYRO3/AXL/MER (TAM) receptor kinase family which encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Cytokine-dependent activation of TAM signaling diverts a proinflammatory pathway to provide an intrinsic feedback inhibitor of both TLR-and cytokine-driven immune responses (1). c-MER is essential regulators of mammalian spermatogenesis (2). Mutations in c-MER gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP)